1.
Nat Struct Mol Biol
; 21(11): 1013-5, 2014 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25291599
RESUMO
PnuC transporters catalyze cellular uptake of the NAD+ precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3+1+3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.